Erythromycins and process for their preparation

Details Erythromycins and process for their preparation Erythromycins and process for their preparation

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01) C07D 498/18 (2006.01) C12N 9/88 (2006.01) C12N 15/52 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2259420

Erythromycins, particularly with C- 13 substituents R1 (e.g. C3-C6 cycloalkyl or cycloalkenyl groups) are prepared by fermenting suitable organisms in the presence of R1CO2H. A preferred organism is Saccharopolyspora erythraea preferably containing an integrated plasmid capable of directing synthesis of desired compounds.

Des érythromycines, en particulier des érythromycines contenant de substituants R1 au niveau de C-13 (par exemple, groupes cycloalkyle ou cycloalcényle C3-C6) sont préparées par fermentation d'organismes appropriés en présence de R1CO2H. Un organisme préféré est Saccharopolyspora erythraea, contenant de préférence un plasmide intégré pouvant jouer un rôle dans la synthèse de composés voulus.

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