Erythromycins and process for their preparation

Details Erythromycins and process for their preparation Erythromycins and process for their preparation

C - Chemistry, Metallurgy

12

P

C12P 17/08 (2006.01) C07H 17/04 (2006.01) C07H 17/08 (2006.01) C12N 9/02 (2006.01) C12N 9/04 (2006.01) C12N 15/66 (2006.01) C12N 15/70 (2006.01) C12N 15/76 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2547228

14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may be found by screening, selected from known strains (e.g. Streptomyces eurythermus DSM 40014) or produced by genetically engineering a strain to express a cytochrome P450 enzyme.

La présente invention a trait à des composés de type macrolide à 14 chaînons tels que des érythromycines comportant des groupes fonctionnels à la position 14 et/ou 15 par l'apport d'une matrice aglycone et par l'alimentation d'une souche apte à son hydroxylation à la position 14 et/ou 15. La souche peut être obtenue par criblage, choisie parmi des souches connues (par exemple, Streptomyces eurythermus DSM 40014) ou produite par la recombinaison génétique d'une souche pour l'expression d'une enzyme de cytochrome P450.

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