C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61P 7/06 (2006.01) C07K 14/505 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2352538
The present invention addresses the need for better pharmaceutical agents for treating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.
Cette invention vise à satisfaire la nécessité de disposer de meilleurs agents pharmaceutiques pour traiter les anémies, en proposant des composés érythropoïétiques non glycosylés dérivés de polymères, qui présentent une stabilité et une bioactivité in vivo. Cette invention se rapporte en outre à des procédés pour préparer ces protéines dérivées, ces procédés consistant à utiliser un processus de modification par aldéhydes sans segment de liaison.
Beals John Michael
Glaesner Wolfgang
Micanovic Radmilla
Millican Rohn Lee Jr.
Witcher Derrick Ryan
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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