C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/505 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 7/06 (2006.01) A61P 31/00 (2006.01) C07K 17/08 (2006.01)
Patent
CA 2310536
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to "n" poly(ethylene glycol) groups of the formula -CO-(CH2)x(OCH2CH2)m-OR with the carbonyl of each poly(ethylene glycol) group forming an amide bond with one of said amino groups; wherein R is lower alkyl; x is 2 or 3; m is about 450 to about 900; n is from 1 to 3; and n and m are chosen so that the molecular weight of the conjugate minus the erythropoietin glycoprotein is from 20 kilodaltons to 100 kilodaltons.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
LandOfFree
Erythropoietin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Erythropoietin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Erythropoietin derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1455743