Erythropoietin (epo) peptides and antibodies directed...

C - Chemistry – Metallurgy – 12 – P

Patent

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167/139, 167/37,

C12P 21/08 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 14/505 (2006.01) C07K 16/22 (2006.01) C07K 16/42 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2021912

Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable for purifying EPO, EPO derivatives or EPO peptides. The epitope-specific anti-EPO antibodies according to the invention can also be used for the detection of EPO and, in particular, for the epitope- specific detection of EPO. Additionally described are anti-idiotype antibodies which imitate a receptor region of EPO. Finally, pharmaceuticals which contain the said EPO peptides, anti-EPO antibodies or anti-idiotype antibodies, and diagnostic aids for the detection of EPO or of anti-EPO antibodies, are described.

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