Erythropoietin forms with improved properties

Details Erythropoietin forms with improved properties Erythropoietin forms with improved properties

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/27 (2006.01) A61K 47/48 (2006.01) C07K 14/505 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2391080

The invention relates to novel modified erythropoietin (EPO) forms such as fusion proteins comprising a Fc portion of an Ig molecule and a target molecule having the biological activity of EPO. By selective altering of the amino acid sequences of the erythropoietin moiety as well as of the immunoglobulin moiety and the glycosylation pattern of erythropoietin fusion proteins with enhanced biological activity can be obtained. The invention relates also to novel non-fused EPO molecules which have a pattern of cysteines or disulfide bonding which is distinct from human or animal EPO.

L'invention concerne de nouvelles formes d'érythropoïétine modifiée (EPO), telles que des protéines hybrides contenant une partie Fc d'une molécule Ig et une molécule cible présentant l'activité biologique d'EPO. Par transformation sélective de séquences d'acides aminés de la fraction d'érythropoïétine ainsi que de la fraction d'immunoglobuline et du modèle de la glycosylation de l'érythropoïétine, des protéines hybrides à activité biologique améliorée peuvent être obtenues. L'invention concerne également de nouvelles molécules d'EPO non hybrides qui présentent un modèle de cystéines ou de liaisons disulfure différent de l'EPO humaine ou animale.

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