Erythropoietin variants

Details Erythropoietin variants Erythropoietin variants

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2608379

The present invention relates to novel endogenous variants of erythropoietin (EPO) and their use for treatment or prevention of a condition associated with tissue damage due to cell death (apoptosis, necrosis) and inflammtion, in particular for neuroprotection, e.g. treatment of acute (for example stroke) and chronic disease (for example ALS) of the nervous system.

La présente invention concerne de nouvelles variantes endogènes d'érythropoïétine (EPO) et leur utilisation pour le traitement ou la prévention d'un état associé à une lésion tissulaire résultant de la mort cellulaire (apoptose, nécrose) et de l'inflammation, en particulier pour la neuroprotection, par exemple le traitement de maladies aiguës (comme l'accident vasculaire cérébral) et chroniques (comme la SLA) du système nerveux.

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