Escape mutant of the surface antigen of hepatitis b virus

Details Escape mutant of the surface antigen of hepatitis b virus Escape mutant of the surface antigen of hepatitis b virus

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07H 21/04 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) C12N 5/16 (2006.01) C12N 7/00 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2251260

The invention provides an isolated mutant hepatitis B surface antigen protein which comprises an amino acid sequence of a surface antigen protein of hepatitis B virus which infects humans, in which the amino acid at position 121 is not cysteine and at least one of the amino acids at positions 120, 122, 123, 147, or 149 is not a conserved amino acid for its position. The invention also provides a method for detecting in a sample a mutant hepatitis B surface antigen protein or a particle containing the protein.

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