Escherichia coli csra gene, protein encoded thereby, and...

Details Escherichia coli csra gene, protein encoded thereby, and... Escherichia coli csra gene, protein encoded thereby, and...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/245 (2006.01) C12N 15/01 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2168008

The invention includes a gene encoding E. coli csrA, the protein encoded thereby and methods of use thereof. This gene is shown to be n negative regulator of the glycogen synthesis gene glgC and glgB as well as to inhibit or activate a large number of other genes involved in glycogen synthesis, gluconeogenesis and glycolysis. This gene can be used to alter the metabolism or functional properties of a cell.

L'invention concerne un gène codant E. coli csrA, la protéine codée par ce dernier et leurs procédés d'utilisation. On a démontré que ce gène est un régulateur négatif du gène de synthèse du glycogène glgC et glgB, et inhibe ou active un grand nombre d'autres gènes impliqués dans la synthèse du glycogène dans la glycogénèse et la glycolyse. Ce gène peut être utilisé pour modifier le métabolisme ou les propriétés fonctionnelles d'une cellule.

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