Escherichia coli immunogens with improved solubility

Details Escherichia coli immunogens with improved solubility Escherichia coli immunogens with improved solubility

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) A61K 39/02 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2716210

Variants of the pathogenic E. coli 'AcfD precursor' have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.

L'invention identifie des variantes du « précurseur AcfD » d'E. coli pathogène avec une solubilité améliorée telle que comparée à la protéine AcfD native qui génère une réponse immunitaire essentiellement semblable chez un sujet à celle de la protéine AcfD native.

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