Essential bacterial genes and their use

Details Essential bacterial genes and their use Essential bacterial genes and their use

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) C07K 14/195 (2006.01) C07K 14/245 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2309212

Disclosed are two genes, termed "yphC" and "yqjK", found in Streptococcus pneumoniae, which are essential for survival for a wide range of bacteria. These genes and the essential polypeptides that they encode, as well as homologs and orthologs thereof, can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

Les deux gènes de l'invention, en l'occurrence "yphC" et yqjK", que l'on a découvert chez Streptococcus pneumoniae, sont essentiels pour la survie d'une vaste gamme de bactéries. Ces gènes et les polypeptides essentiels qu'ils codent, ainsi que certains de leurs homologues et orthologues, peuvent s'utiliser pour identifier des agents antibactériens destinés au traitement d'un large spectre d'infections bactériennes.

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