Essential bacterial genes and their use

Details Essential bacterial genes and their use Essential bacterial genes and their use

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/315 (2006.01) C07K 14/32 (2006.01) C07K 16/12 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2315252

Disclosed are 23 genes, termed "GEP" genes, found in streptococcus pneumonia, which are located within operons that are essential for survival. Also disclosed is a related essential gene found in Bacillus subtilis. These genes and the polypeptides that they encode, as well as homologs thereof, can be used to identify antibacterial agents for treating bacterial infections such as streptococcal pneumonia.

L'invention se rapporte à 23 gènes désignés par le terme "GEP", rencontrés chez Streptococcus pneumonia et situés dans des opérons qui sont essentiels pour la survie. Elle concerne également un gène essentiel correspondant, trouvé chez Bacillus subtilis. On peut utiliser ces gènes et les polypeptides pour lesquels ils codent, ainsi que leurs homologues, pour identifier des agents antibactériens permettant de traiter des infections bactériennes telles que la pneumonie à streptocoques.

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