C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2728804
The subject matter of the invention is a functional population of human brown adipocytes, in which the expression of UCP1, CIDEA, CPT1B and Bc12 is higher, the expression of Bax is lower and the expression of PPAR-alpha, PGC-1alpha, PGC-1beta and PRDM16 is similar compared with the corresponding expressions of a population of human white adipocytes. The invention also relates to a method for differentiation of hMADS cells into the functional population of human brown adipocytes, to a method for conversion of a population of human white adipocytes into the functional population of human brown adipocytes, and also to a method of screening for molecules capable of modulating the bodyweight in an individual.
L'invention a pour objet une population d'adipocytes bruns humains fonctionnelle, dans laquelle l'expression de UCP1, CIDEA, CPT1B et Bc12 est supérieure, l'expression de Bax est inférieure, et l'expression de PPAR alpha, PGC1 alpha, PGC1 bêta et PRDM16 est similaire par rapport aux expressions correspondantes d'une population d'adipocytes blancs humains. L'invention concerne également un procédé de différenciation de cellules hMADS en la population d'adipocytes bruns humains fonctionnelle, un procédé de conversion d'une population d'adipocytes blancs humains en la population d'adipocytes bruns humains fonctionnelle, ainsi qu'une méthode de criblage de molécules susceptibles de moduler le poids corporel chez un sujet.
Ailhaud Gerard Paul
Amri Ez-Zoubir
Dani Christian Jean Lucien
Elabd Christian
Centre National de La Recherche Scientifique (cnrs)
Fasken Martineau Dumoulin Llp
Universite de Nice - Sophia Antipolis
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