Establishment of biological cut-off values for predicting...

Details Establishment of biological cut-off values for predicting... Establishment of biological cut-off values for predicting...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2425772

The present invention concerns methods and systems for improving the accuracy of predicting resistance of a disease to a therapy. In one embodiment of the invention, mean and standard deviation (SD) values of fold change in normalized sensitivity, relative to a laboratory wild type standard pathogen or malignant cell are calculated to demonstrate that the patient samples display inherently different degrees of variation in susceptibility to each therapy. In another embodiment, the 2xSD value for each therapy is used as the cut-off between sensitive (within normal susceptible range) and resistant (above normal susceptible range).

L'invention concerne des procédés et des systèmes permettant d'améliorer la précision des prévisions relatives à la résistance d'une maladie à la thérapie. Selon une variante, des valeurs d'écart type moyen (SD) relatives au changement, en proportion, de la sensibilité normalisée, par rapport à une cellule pathogène ou maligne de type sauvage (en laboratoire) sont calculées. On montre ainsi que les échantillons du patient présentent des degrés de variation inhérente qui diffèrent en termes de susceptibilité vis-à-vis d'une thérapie. Selon une autre variante, la valeur 2xSD pour chaque thérapie est utilisée comme seuil entre la sensibilité (dans une gamme de susceptibilité normale) et la résistance (au-dessus d'une gamme de susceptibilité normale).

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