C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/81 (2006.01) A61K 31/216 (2006.01) A61K 31/44 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07C 237/42 (2006.01) C07D 207/27 (2006.01) C07D 211/46 (2006.01) C07D 211/62 (2006.01) C07D 213/30 (2006.01) C07D 213/56 (2006.01) C07D 257/04 (2006.01) C07D 271/06 (2006.01) C07D 295/192 (2006.01) C07D 333/16 (2006.01)
Patent
CA 2584398
Disclosed are an ester compound represented by the general formula [1] below or a pharmaceutically acceptable salt thereof, and use of them. The compound represented by the above general formula [1] or a pharmaceutically acceptable salt thereof is very quickly eliminated from the body when compared with conventional MTP inhibitors, while having excellent MTP inhibitory activity. Consequently, the compound or a pharmaceutically acceptable salt thereof is useful as a drug for preventing or treating hyperlipemia and the like.
La présente invention a pour objet un dérivé d~ester de formule générale [1] ci-dessous, ou un sel de qualité pharmaceutique de ce dérivé, ainsi que les applications de ces composés. [1] Ledit composé de formule générale [1] ci-avant, ou un sel de qualité pharmaceutique dudit composé, peuvent être très rapidement éliminés par l'organisme par comparaison avec les inhibiteurs de MTP conventionnels, tout en présentant eux-mêmes une excellente activité inhibitrice de MTP. Ledit composé ou son sel peuvent ainsi être employés en tant que médicaments dans le traitement prophylactique ou thérapeutique de l~hyperlipémie ou d~affections similaires.
Hagiwara Atsushi
Iida Akio
Ikenogami Taku
Kurihara Kazunori
Takahashi Mitsuru
Japan Tabacco Inc.
Ridout & Maybee Llp
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