Ester derivatives

Details Ester derivatives Ester derivatives

C - Chemistry, Metallurgy

07

D

C07D 309/12 (2006.01) A61K 31/22 (2006.01) A61K 31/35 (2006.01) A61K 31/42 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 265/36 (2006.01) C07D 279/16 (2006.01) C07D 307/20 (2006.01) C07D 311/22 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 309/10 (2006.01)

Patent

CA 2099819

A B S T R A C T ESTER DERIVATIVES The invention concerns ester derivatives of the formula I Image wherein Ar is phenyl, naphthyl, indenyl, indanyl, a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur, or a 9-membered or 10-membered bicyclic heterocyclic moiety containing one heteroatom group selected from oxygen, sulphur, sulphinyl, sulphonyl and imino; Al is a direct link to the oxygen atom of the ester group or Al is (1-3C)alkylene; each of R4 and R5 is hydrogen or (1-4C)alkyl; R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R2 and R3 together form a group of the formula -A2-X-A3- wherein each of A2 and A3 is independently (1-3C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino; or pharmaceutically-acceptable salts thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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