Ester-substituted diaminedithiols and radiolabeled complexes...

Details Ester-substituted diaminedithiols and radiolabeled complexes... Ester-substituted diaminedithiols and radiolabeled complexes...

C - Chemistry, Metallurgy

07

F

260/426, 167/47,

C07F 13/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1271195

TITLE ESTER-SUBSTITUTED DIAMINEDITHIOLS AND RADIOLABELED COMPLEXES THEREOF ABSTRACT OF THE DISCLOSURE Radiophamaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula -A-COOR- where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substitued diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclides.

559230

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