C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.38
C12N 9/18 (2006.01) C12P 7/40 (2006.01) C12P 7/62 (2006.01) C12P 7/64 (2006.01) C12P 17/00 (2006.01) C12P 41/00 (2006.01)
Patent
CA 1341324
A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula (see formula I) or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula (see formula II) wherein R2 is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.
617105
Bertola Mauro A.
Koger Hein S.
Marx Arthur F.
Phillips Gareth T.
Quax Wilhelmus J.
Dsm Ip Assets B.v.
Gist - Brocades N.v.
Osler Hoskin & Harcourt Llp
Shell Internationale Research Maatschappij B.v.
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