Esterase gene and its use

Details Esterase gene and its use Esterase gene and its use

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C12N 9/18 (2006.01) C12P 7/38 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2217147

The present invention is directed to an isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: (see fig. I) wherein R1 is hydrogen or methyl, and R2 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10alkynyl, C1-C4 haloalkyl, a C5-C9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C5-C9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (r)-form, and hybridizing to the base sequence of SEQ ID NO:1. It is useful for the industrially favourable production of optically active cyclopentenolones of formula I which serve as intermediates in the preparation of drugs, agricultural chemicals or other active products.

L'invention porte sur un gène isolé d'estérase, codant une estérase apte à provoquer l'hydrolyse asymétrique d'un ester d'acide carboxylique d'une hydroxypenténone de formule I (voir fig. I), où R1 est un hydrogène ou un méthyle, et R2 est un groupe alkyle C1-C10, alcényle C2-C10, alcynyle C2-C10 ou haloalkyle C1-C4, une fraction aliphatique C5-C9 pouvant être facultativement protégée au niveau du groupe carboxyle terminal, pour former l'hydroxypenténone de formule I sous forme (R), et s'hybrider à la séquence de bases de SEQ ID NO:1. Il est utile pour la production commerciale d'hydroxypenténones optiquement actives de formule I, qui servent pour la préparation de médicaments, de produits chimiques agricoles ou d'autres ingrédients actifs.

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