Esters and amides as pla2 inhibitors

Details Esters and amides as pla2 inhibitors Esters and amides as pla2 inhibitors

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) A61K 31/16 (2006.01) A61K 31/21 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 237/22 (2006.01) C07D 209/42 (2006.01) C07D 215/48 (2006.01) C07D 217/26 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2227466

The present invention relates to a novel fatty acid derivative of formula (I), wherein R1 is acyl group; R2 is acyl(lower)alkyl; R3 is hydrogen, aryl(lower)alkyl, etc.; R4 is acyl(lower)alkyl; and X is -O-, -NH- or formula (II) [wherein R5 is lower alkyl, etc.]; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.

La présente invention concerne un dérivé d'acide gras représenté par la formule générale (I) dans laquelle R?1¿ est un groupe acyle, R?2¿ est alkyle (inférieur) d'acyle, R?3¿ est hydrogène, alkyle (inférieur) d'aryle, etc., R?4¿ est alkyle (inférieur) d'acyle, et X est -O-, -NH- ou un groupe représenté par la formule particulière (II). Dans cette formule particulière (II), R?5¿ est alkyle inférieur, etc. L'invention concerne également un sel de ce dérivé utile comme médicament et admis en pharmacie, des procédés de préparation du dérivé d'acide gras ou de l'un de ses sels, et enfin une composition pharmaceutique comprenant ce dérivé d'acide gras ou l'un de ses sels admis en pharmacie.

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