Esters in position 20 of camptothecins

C - Chemistry – Metallurgy – 07 – D

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C07D 491/22 (2006.01) A61K 31/4375 (2006.01) A61P 31/12 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2487252

Formula (I) compounds are described: (I) where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.

L'invention concerne des composés représentés par la formule (I), dans laquelle les groupes sont tels que définis dans la description. L'invention concerne également des mélanges racémiques, des énantiomères individuels, des diastéréoisomères individuels, des mélanges et des sels de ces composés acceptables sur le plan pharmaceutique. Ces composés sont des inhibiteurs de la topoisomérase I.

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