Esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycarbonyl or...

Details Esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycarbonyl or... Esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycarbonyl or...

C - Chemistry, Metallurgy

07

D

167/228, 260/294

C07D 211/90 (2006.01) A61K 31/455 (2006.01)

Patent

CA 1261338

ABSTRACT: Esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycarbonyl or alkoxyalkoxycarbonyl)-4-(substituted phenyl)-pyridine-5- -carboxylic acid. Image (I) Esters I (Ar=3-nitrophenyl or 2,3-dichlorophenyl, A=C2-C6 alkylene, R=C1-C6 alkyl optionally C1-C6 alkoxy monosubstituted, R1=C1-C4 alkyl) have antihypertensive activity and are effective against coronary heart diseases. They are prepared starting from the aldehyde ArCHO and esters of acetoacetic acid and 3-aminocrotonic acid. Pharmaceutical preparations containing them are also described.

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