Esters of 3-demethylthiocolchicine and n-acyl analogs

Details Esters of 3-demethylthiocolchicine and n-acyl analogs Esters of 3-demethylthiocolchicine and n-acyl analogs

C - Chemistry, Metallurgy

07

C

167/248, 260/235

C07C 323/41 (2006.01) A61K 31/645 (1995.01)

Patent

CA 1338432

The present invention relates to esters of 3-demethylthiocolchicine and N-acyl analogs thereof having the following formula: Image wherein R is O-CO-alkyl, O-CO-CH2Oalkyl, O-CO-Phenyl, O-COOalkyl; the alkyl group having from 1 to 4 carbon atoms and the Ac group representing acetyl and its higher homologs, benzoyl, alkoxyacetyl, or haloacetyl. The invention further relates to processes for preparing these ester compounds, pharmaceutical compositions thereof and methods for treating diseases such as gout, Mediterranean fever and liver disorders.

609341

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