C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/22 (2006.01) A61K 31/22 (2006.01)
Patent
CA 2087084
Esters of acyl L-carnitines of general formula (I) (see Formula I) wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl; n is an integer comprised between 7 and 15, particularly 10; and, X- is the anion of a pharmacologically acceptable acid are endowed with potent antimycotic activity particularly against yeast life fungi, such as Candida albicans, the aetiologic went of candidiasis and against filamentous fungi, such as Aspergillus fumigatus, the aetiologic agent of aspergillosis. Orally or parenterally administrable or topically applicable pharmaceutical compositions comprise an ester of formula (I) as active ingredient.
Foresta Piero
Misiti Domenico
Santaniello Mose
Tinti Maria Ornella
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.
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