Esters of cyclopropane carboxylic acid derivatives and...

C - Chemistry – Metallurgy – 07 – C

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260/479.1

C07C 69/74 (2006.01) C07C 67/22 (2006.01) C07C 69/743 (2006.01)

Patent

CA 1127658

A B S T R A C T Process for the preparation of an ester useful as an intermediate in the manufacture of insecticidal pyrethroids having the general formula: (I) Image wherein each of R1 and R2 independently represents an alkyl group of 1 to 4 carbon atoms or R1 and R2 together represent an alkylene group of up to 5 carbon atoms,each of X1 and X2 independently represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms, a halogen atom, or X1 and X2 together represent an alkylene group of up to 5 carbon atoms, or X1 represents a hydrogen atom and X2 a 2-halovinyl group, a 2,2-dihalovinyl group or a 2-methyl-1-pro- penyl group and R represents 2-methoxyethyl, or a 2-ethoxyethyl, or a 3,6-dioxaheptyl, or a 3,6-dioxaoctyl group characterized in that a substituted cyclopropanecarbonitrile having the general formula (II) Image wherein R1, R2, X1 and X2 have the same meaning as in formula I, is reacted with 2-methoxyethanol or 2-ethoxyethanol under sub- stantially anhydrous conditions and in the presence of mineral acid acting as reaction catalyst and as scavenger for ammonia produced during the reaction.

312944

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