Esters of dihydrolysergic acid and related compounds

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

167/231, 260/206

C07D 457/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1292223

ABSTRACT OF THE DISCLSOURE The present invention as disclosed provides ergolines of Formula (III): Image wherein R is primary or secondary C1-8 alkyl, C2-4 alkenyl-CH2, C3-8 cycloalkyl or C3-6 cycloalkyl substituted C1-5 primary or secondary alkyl, the total number of carbon atoms in R not to exceed 8; R1 is allyl, H or C1-4 straight-chain alkyl; and R2 is Image wherein n is 0-4 and m is 1 or 2 except that, when n is 0, the ester function may not be attached to the cyclic ether ring alpha to the ring oxygen; (b) Image wherein R3 and R4 can be individually H, CH3 or C2H5; n can be 0, 1 or 2; R5 can be OH, OC1-3 alkyl, chloro, bromo, fluoro, CH3, CF3 or C2H5 when n is 1 or 2; R5 can be phenyl when n is 1; and R5 can be methylenedioxy when n is 2; or (c) monofluoro-, difluoro- or trifluoro- C2-5 alkyl; and pharmaceutically acceptable salts thereof. These compounds of Formula (III), where R1 is other than hydrogen,are useful as central or peripheral serotonin 5HT2 receptor antagonists and thus can be used in treating disease states in which an excess of circulating serotonin is a major contributing cause, eg. hypertension. The compounds of this invention wherein is H are useful as intermediates.

525125

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Esters of dihydrolysergic acid and related compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Esters of dihydrolysergic acid and related compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Esters of dihydrolysergic acid and related compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1225690

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.