Esters of n-alkyl-nortropines and their quaternary...

Details Esters of n-alkyl-nortropines and their quaternary... Esters of n-alkyl-nortropines and their quaternary...

C - Chemistry, Metallurgy

07

D

167/230, 260/270

C07D 451/10 (2006.01) A61K 31/46 (2006.01) C07D 451/06 (2006.01)

Patent

CA 1303043

-1- "Esters of N-alKyl-nortropines and their quaternary derivatives having anti-bronchospastic activity, process for their prepararation and pharmaceutical compositions containing them" ABSTRACT The esters of M-alkyl-nortropines with phenyl-cyclohexen-carboxylic and phenyl-cyclohexen-acetic acids and their quaternary ammonium derivatives with alkyl halides and alkyl sulphates having general formula: Image X- wherein when A= Image R= -CH2-CH3 -CH2-CH2-CH3 -CH(CH3)2 and when A= Image R= -CH3 -CH2-CH3 -CH2-CH2-CH3 -CH(CH3)2 whereas R'= -, -H, -CH3, -CH2-CH3, -CH2-CH2-CH3, -CH(CH3)2, -CH2-CH2-CH2-CH3, -CH2-CH-(CH3)2 X-= Cl, Br, J, CH3SO4 show anti-bronchospastic activity. The invention relates also to the processes for their preparation and to the pharmaceutical compositions containing them.

529378

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