Estimation of clinical cut-offs

Details Estimation of clinical cut-offs Estimation of clinical cut-offs

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) G06F 19/18 (2011.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2557790

Methods and systems for improving the accuracy of predicting resistance of a disease to a drug are described. More specifically, methods for assessing the impact of pre-existing variations in drug susceptibility, whether naturally occurring or selected by previous drug exposure, on treatment response in order to establish clinically relevant cut-off values for phenotypic or genotypic resistance tests are described.

La présente invention a trait à des procédés et des systèmes pour l'amélioration de la précision de prévision de la résistance d'une maladie à un médicament. De manière plus spécifique, l'invention a trait à des procédés permettant l'évaluation de l'impact de variations préexistantes dans la susceptibilité aux médicaments, naturelles ou choisies par une exposition précédente aux médicaments, lors d'une réaction à un traitement en vue de l'établissement de valeurs de relevés de pertinence clinique pour des essais de résistance phénotypique ou génotypique.

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