Estratriene derivatives

Details Estratriene derivatives Estratriene derivatives

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2525651

Compounds and methods for modulating mesenchymal cell function, for instance smooth muscle and fibroblast proliferation or cytokine expression, and for treating conditions associated with mesenchymal cell function, for instance airway hyperresponsiveness associated with asthma. The compounds also supress inflammation. The compounds are a class of estratriene derivates, and includes various derivatives of 2-methoxyestradiol comprising a group A, including a substituted aromatic substituent in the 2-, 6- or 17- position.

L'invention concerne des composés et des méthodes servant à moduler la fonction cellulaire mésenchymateuse, par exemple, du muscle lisse et de la prolifération de fibroblaste ou de l'expression de cytokine et à traiter des troubles liés à la fonction cellulaire mésenchymateuse, à savoir l'hypersensibilité des voies aériennes liée à l'asthme. Ces composés permettent également de supprimer une inflammation. Ils font partie d'une classe des dérivés d'estratriène et contiennent divers dérivés de 2-méthoxyestradiol qui englobe un groupe A comprenant un substituant aromatique substitué en position 2, 6 ou 17.

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