Estrene steroids as neurochemical initiators of change in...

C - Chemistry – Metallurgy – 07 – J

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C07J 13/00 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) C07J 1/00 (2006.01) C07J 3/00 (2006.01)

Patent

CA 2165324

The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Estrene steroid, or a pharmaceutical composition containing an Estrene steroid, such that the ligand semiochemical binds to a specific neuroepithelial receptor. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

L'invention concerne un procédé de modification de la fonction hypothalamique chez un individu. Ledit procédé consiste à administrer par voie nasale un produit écomone humain tel qu'un stéroïde d'estrène, ou une composition pharmaceutique contenant un stéroïde d'estrane de sorte que le produit écomone ligand se fixe sur un récepteur neuroépithélial spécifique. Ledit stéroïde est, de préférence, administré sous forme de composition pharmaceutique contenant un ou plusieurs excipients pharmaceutiquement acceptables. L'invention porte également sur des compositions pharmaceutiques contenant lesdits stéroïdes.

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