Estrogen agonist/antagonist metabolites

Details Estrogen agonist/antagonist metabolites Estrogen agonist/antagonist metabolites

C - Chemistry, Metallurgy

07

D

C07D 295/08 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) C07C 229/12 (2006.01) C07D 207/12 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 295/092 (2006.01)

Patent

CA 2405070

This invention relates to compounds that are mammalian metabolites of (-)-cis- 6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalene- 2-ol. The compounds of the invention can be used as standards for analytical assays or as intermediates for the further chemical synthesis or biosynthesis of chemical entities. The invention also relates to pharmaceutical compositions for the treatment of disease and methods of treating disease.

L'invention concerne des composés qui sont des métabolites de mammifères de (-)-cis-6-phényl-5-[4-(2-pyrrolidin-1-yl-éthoxy)-phényl]-5,6,7,8-tétrahydro-naphthalin-2-ol. Les composés de cette invention peuvent être utilisés comme étalons pour des essais analytiques ou comme intermédiaires pour la synthèse chimique ou la biosynthèse ultérieure d'entités chimiques. Cette invention concerne également des compositions pharmaceutiques pour le traitement de maladies ainsi que des procédés de traitement de maladies.

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