Estrogen-containing active substance plaster

Details Estrogen-containing active substance plaster Estrogen-containing active substance plaster

A - Human Necessities

61

K

167/159

A61K 9/70 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61L 15/44 (2006.01) A61L 15/58 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2027053

The present invention relates to active substance plasters for the controlled release of active substances to the skin consisting of a backing layer, an adhesive film connected therewith which film is water-soluble and consists of pressure-sensitive adhesive which comprises water-swellable polymers and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, in which plasters the pressure-sensitive adhesive is based on homo and/or copolymers with at least one derivative of the acrylic or methacrylic acid, and which comprise as active substances, partially or completely dissolved in the adhesive, at a concentration of 0.5 to 10.0%-wt estrogens and their pharmaceutically acceptable derivatives along or in combination with gestagens.

La présente invention porte sur des diachylons contenant une substance active libérable sur la peau de façon contrôlée; ces diachylons sont constitués d'une couche de support reliée à une pellicule d'adhésif autocollant hydrosoluble, contenant des polymères gonflables à l'eau et dans laquelle la substance active est au moins partiellement soluble, et d'une couche protectrice enlevable qui recouvre la couche adhésive; la pellicule d'adhésif autocollant, qui est à base d'homopolymères et/ou de copolymères d'au moins un dérivé d'acide acrylique ou d'acide métacrylique, contient, dissoute partiellement ou complètement dans l'adhésif, une concentration de 0,5 à 10,0 % (en masse) de substance active, c'est-à-dire des estrogènes et leurs dérivés acceptables du point de vue pharmaceutique accompagnés de ou en combinaison avec des gestagènes.

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