C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 43/00 (2006.01) A61K 31/282 (2006.01) A61K 31/58 (2006.01) A61P 35/00 (2006.01) C07F 15/00 (2006.01)
Patent
CA 2423454
This invention relates to a compound of formula : (see formula I) wherein X may be -CH2-O-CH2- or -CH2-; n may be 1, 2, 3, 4, or 5 when X is -CH2-O-CH2-; or n may be 2, 3, 4, 5, 6, 7, 8, 9 or 10 when X is -CH2-; o may be 1, 2, or 3, wherein Y may be O or 17.beta.-OH; where the dotted line represents the presence or absence of a second chemical bond; R1 may be selected from the group consisting of H, a straight alkyl group of 1 to 5 carbon atoms, and a branched alkyl group of 3 to 5 carbon atoms; and R2 is selected for the group consisting of H, a straight alkyl group of 1 to 4 carbon atoms, a branched alkyl group of 3 to 4 carbon atoms, F, Cl, Br, I, -CF3, - NO2, -OR1, -COR1 and -CH2OH, where R1 is as defined above. These compounds possess anticancer activity against hormone-dependent breast, uterus as well as ovarian cancers.
Berube Gervais
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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