C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2559144
The present invention provides isolated polypeptides having an amino acid sequence having at least 70 % identity to SEQ ID N0:20, wherein the polypeptide has ER-.alpha.36 activity. The invention further provides methods for identifying agents that bind to such polypeptides, methods for detecting such polypeptides, and methods for altering the activity of such polypeptides. Also provided are antibodies that specifically bind to an amino acid sequence depicted at SEQ ID NO:1, or an immunogenic fragment thereof, and methods for making and using such antibodies.
L'invention concerne des polypeptides isolés qui comprennent une séquence d'acides aminés présentant une identité s'élevant à au moins 70 % par rapport à la SEQ ID NO:20, lesdits polypeptides présentant une activité ER-.alpha.36. L'invention concerne également des procédés d'identification d'agents qui se lient auxdits polypeptides, des procédés de détection desdits polypeptides, et des procédés d'altération de l'activité desdits polypeptides. L'invention concerne en outre des anticorps qui se lient de manière spécifique à une séquence d'acides aminés de type SEQ ID NO:1, ou un fragment immunogène associé, ainsi que des procédés de production et d'utilisation desdits anticorps.
Creighton University
Smart & Biggar
LandOfFree
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