Estrogen receptor-.beta. ligands

Details Estrogen receptor-.beta. ligands Estrogen receptor-.beta. ligands

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61K 31/00 (2006.01) A61K 31/122 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/37 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/536 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2370126

A method for treating a disease associated with the estrogen receptor-.beta., comprising the step of administering a therapeutically - effective amount of a compound that satisfies the equation: (Ki.alpha.A/Ki.beta.A)/(Ki.alpha.E/Ki.beta.E)>1, optionally having the general structure (I) including among other flavones, isaflavones, coumarins and chromanones for treating a disease selected from the group consisting of Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis, cardiovascular disease, rheumatoid arthritis and prostate cancer.

L'invention concerne un procédé permettant de traiter une maladie associée au récepteur -.beta. de l'oestrogène. Ce procédé consiste à administrer une quantité thérapeutiquement efficace d'un composé qui répond à l'équation: (Ki.alpha.A/Ki.beta.A)/(Ki.alpha.E/Ki.beta.E)>1 et présente la structure générale (I).

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