Estrogen receptor ligands

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/00 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 333/58 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 417/04 (2006.01) C07J 41/00 (2006.01) C07K 14/72 (2006.01)

Patent

CA 2292611

Crystal comprising at least part of the ER.alpha. ligand binding domain, optionally bound to a ligand, ligands that bind to ER receptors, and methods of designing them, and a homology model of the ER.beta. receptor.

L'invention se rapporte à un cristal renfermant au moins une partie du domaine de liaison de ligands aux récepteurs .alpha. d'oestrogènes ER.alpha., ce cristal étant éventuellement lié à un ligand; à des ligands qui se lient aux récepteurs d'oestrogènes (ER); enfin à des procédés permettant de concevoir ces récepteurs ainsi qu'à un modèle d'homologie du récepteur .beta. d'oestrogènes ER.beta..

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