Estrogen receptor modulators

Details Estrogen receptor modulators Estrogen receptor modulators

C - Chemistry, Metallurgy

07

C

C07C 49/755 (2006.01) A61K 31/05 (2006.01) A61K 31/122 (2006.01) A61K 31/15 (2006.01) A61K 31/19 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/445 (2006.01) C07C 39/23 (2006.01) C07C 39/42 (2006.01) C07C 45/28 (2006.01) C07C 45/46 (2006.01) C07C 45/63 (2006.01) C07C 45/65 (2006.01) C07C 45/68 (2006.01) C07C 45/69 (2006.01) C07C 45/71 (2006.01) C07C 45/72 (2006.01) C07C 45/73 (2006.01) C07C 45/74 (2006.01) C07C 45/75 (2006.01) C07C 49/543 (2006.01) C07C 49/553 (2006.01) C07C 49/747 (2006.01)

Patent

CA 2400626

The present invention relates to compounds and derivatives thereof, of the formula: (see formula I) their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

L'invention concerne des composés et leurs dérivés, leur synthèse et leurs utilisations en tant que modulateurs de récepteurs d'oestrogène. Les composés de l'invention sont des ligands pour les récepteurs d'oestrogène et en tant que tels peuvent être utiles dans le traitement ou la prévention de troubles variés associés au fonctionnement d'oestrogène tels que: perte osseuse, fractures d'os, ostéoporose, dégénérescence des cartilages, endométriose, myome de l'utérus, bouffées de chaleur, cholestérol à niveau élevé de LDL, maladie cardio-vasculaire, déficience de fonction cognitive, troubles de dégénérescence cérébrale, rétinose, gynécomastie, prolifération cellulaire de muscle lisse vasculaire, obésité, incontinence, et cancer, en particulier du sein, de l'utérus et de la prostate.

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