Estrogen receptor modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/56 (2006.01) A61K 31/404 (2006.01) A61P 5/30 (2006.01) C07D 231/56 (2006.01) C07D 235/02 (2006.01) C07D 235/04 (2006.01) C07D 249/16 (2006.01) C07D 249/18 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2428019

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

L'invention concerne des composés et leurs dérivés, leur synthèse et leur utilisation comme modulateurs de récepteurs d'oestrogènes. Les composés sont des ligands pour récepteurs d'oestrogènes et comme tels, peuvent servir dans le traitement ou la prévention de divers états se rapportant au fonctionnement des oestrogènes, notamment: perte osseuse, fractures d'os, ostéoporose, dégénérescence des cartilages, endométriose, myome de l'utérus, bouffées de chaleur, cholestérol à niveau élevé de LDL, maladie cardio-vasculaire, déficience du fonctionnement cognitif, troubles de dégénérescence cérébrale, restinose, gynécomastie, prolifération de cellules de muscles vasculaires lisses, obésité, incontinence et cancer, en particulier du sein, de l'utérus et de la prostate.

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