Estrogen receptor-related receptor alpha (err.alpha.) and...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/025 (2006.01) A61K 31/05 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 38/17 (2006.01) A61P 19/02 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2442685

Estrogen related receptor .alpha. (ERR.alpha.) is involved in control of cartilage formation in mammals. Increasing ERR.alpha. activity causes stimulation of cartilage formation, providing a means of therapeutic intervention in diseases such asarthritis which involve cartilage destruction. Compounds may be screened for their potential as therapeutics by screening their effect on ERR.alpha. cartilage promoting activity.

Le récepteur .alpha. lié aux oestrogènes (ERR.alpha.) est impliqué dans le contrôle de la formation de cartilage chez les mammifères. L'augmentation de l'activité de ERR.alpha. provoque une stimulation de la formation de cartilage, représentant un moyen d'intervention thérapeutique dans le cas de maladies telles que l'arthrose impliquant la destruction du cartilage. Des composés peuvent être criblés au sujet de leur potentiel en tant qu'agents thérapeutiques par criblage de leur effet sur l'activité de formation de cartilage de ERR.alpha..

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