C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) A61K 31/05 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/567 (2006.01) C07J 63/00 (2006.01) C07J 73/00 (2006.01)
Patent
CA 2168850
The application discloses methods of making medicaments for treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of general formulae found above in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
L'invention concerne des méthodes de fabrication de médicaments pour le traitement de maladies mammaliennes caractérisées par une mitose anormale des cellules. Ce traitement consiste à administrer des dérivés d'estradiol, y compris ceux qui contiennent des motifs structurels A-4 de colchicine ou de combrétastatine de la formule générale indiquée ci-dessus, en appliquant un dosage suffisant pour inhiber la mitose des cellules. La demande porte sur les nouveaux composés utilisés avec ces méthodes.
D'amato Robert John
Folkman Moses Judah
Finlayson & Singlehurst
The Children's Medical Center Corporation
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