Estrone-derivatives having cytoprotective activity

Details Estrone-derivatives having cytoprotective activity Estrone-derivatives having cytoprotective activity

C - Chemistry, Metallurgy

07

J

C07J 1/00 (2006.01) A61K 31/565 (2006.01) A61K 31/566 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2427817

The present invention is directed to modified, hydroxy-bearing aromatic ring structures having cytoprotective activity. More specifically, in a first embodiment the present invention is directed to phenolic compounds, and in particular steroids (e.g., estrogens), wherein a non-fused polycyclic, hydrophobic substituent is attached to the hydroxy-substituted A-ring thereof. The present invention is further directed to a process for conferring cytoprotection to a population of cells involving the administration of the compounds.

L'invention porte sur des structures de cycles aromatiques à substitution hydroxy et à activité cytoprotectrice, plus spécifiquement sur des composés phénoliques et plus particulièrement des stéroïdes (par exemple des oestrogènes) au cycle A à substitution hydroxy desquelles est fixé un substituant polycyclique hydrophobe non fusionné. L'invention porte en outre sur un procédé conférant la cytoprotection à une population de cellules impliquant l'administration de ces composés.

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