Estrone sulfamate inhibitors of estrone sulfatase, and...

C - Chemistry – Metallurgy – 07 – J

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61P 5/30 (2006.01)

Patent

CA 2318349

Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alkyl, or together form a cyclic substituent (II) wherein Q is NH, O or CH2, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (1) to treat estrogen-dependent disorders are provided as well.

La présente invention concerne de nouveaux composés utiles en tant qu'inhibiteurs de l'oestrone sulfatase. Ces composés sont représentés par la formule développée (I), dans laquelle r1 représente une double liaison facultative, R<1> et R<2> sont sélectionnés dans le groupe constitué d'hydrogène et d'alkyle inférieur, ou forment, ensemble, un substituant cyclique (II), dans lequel Q représente NH, O ou CH2, les divers autres substituants état définis dans le descriptif. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés de formule (I) pour traiter des troubles liés aux oestrogènes.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Estrone sulfamate inhibitors of estrone sulfatase, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Estrone sulfamate inhibitors of estrone sulfatase, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Estrone sulfamate inhibitors of estrone sulfatase, and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1588135

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.