Ethanolates of sodium-hydrogen exchanger type-1 inhibitor

Details Ethanolates of sodium-hydrogen exchanger type-1 inhibitor Ethanolates of sodium-hydrogen exchanger type-1 inhibitor

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/41 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2436539

The invention relates to ethanolates of the NHE-1 inhibitor, N-(5-cyclopropyl- 1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine, crystalline forms of the ethanolates, methods of preparing the ethalolates, methods of treatment using the ethanolates and the mesylate salt of the NHE-1 inhibitor prepared using the ethanolates.

La présente invention concerne des éthanolats de l'inhibiteur de NHE-1, N-(-5-cyclopropyl-1-quinolin-e-yl-1h-pyrazole-4-carbonyle)-guanidine, des formes cristallines de ces éthanolats, des techniques de préparation de ces éthanolats, des techniques de traitement utilisant ces éthanolats et le sel de mésylate de l'inhibiteur de NHE-1 préparé à l'aide de ces éthanolats.

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