Ether benzylidene piperidine aryl carboxamide compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 211/70 (2006.01) A61K 31/4427 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2719785

The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or 6-mem-bered heteroaryl moiety, or a benzisoxazole, pyrrolopyridine, or benzotriazole group; or a pharmaceutically acceptable salt there-of; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions con-taining the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, including pain, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleep-ing disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain in-jury, gastrointestinal disorders, hypertension, or cardiovascular disease.

La présente invention porte sur des composés représentés par la Formule (I) dans laquelle Ar est une fraction phényle ou hétéroaryle à 6 chaînons facultativement substituée, ou un groupe benzisoxazole, pyrrolopyridine ou benzotriazole ou sur un sel pharmaceutiquement acceptable de ceux-ci ; sur des procédés de fabrication des composés ; sur des intermédiaires utilisés dans la fabrication des composés ; sur des compositions contenant les composés ; et sur des utilisations des composés dans le traitement de maladies ou affections associées à l'activité de l'hydrolase d'amides d'acides gras (FAAH), dont la douleur, l'incontinence urinaire, lhyperactivité de la vessie, les vomissements, les troubles cognitifs, l'anxiété, la dépression, les troubles du sommeil, les troubles de l'alimentation, les troubles du mouvement, le glaucome, le psoriasis, la sclérose en plaques, les troubles cérébrovasculaires, les lésions du cerveau, les troubles gastro-intestinaux, l'hypertension ou les maladies cardiovasculaires.

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