Ether derivatives

Details Ether derivatives Ether derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/395 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 493/08 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2121199

The invention concerns ether derivatives of the formula I Q1-X-Ar-Q2 I wherein Q1 is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; X is oxy, thio, sulphinyl or sulphonyl; Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazolediyl, thiadiazolediyl or oxadiazolediyl; and Q2 is selected from the groups of the formulae II and III:- Image wherein R1 is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl; R2 is (1-4C)alkyl; and R3 is hydrogen or (1-4C)alkyl; or R2 and R3 are linked to form a methylene, vinylene, ethylene or trimethylene group; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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