Ether derivatives useful as inhibitors of pde4 isozymes

Details Ether derivatives useful as inhibitors of pde4 isozymes Ether derivatives useful as inhibitors of pde4 isozymes

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/44 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 213/82 (2006.01) C07D 277/56 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2436544

Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of the formula (I) wherein j is 0 or 1, provided that when j is 0, n must be 2; k is 0 or 1; m is 1, 2, or 3; n is 1 or 2; W1 and W2 are -O-; -S(=O)t-, where t is 0, 1, or 2, or -N(R3)-; Y is =C(R1a)-, or -[N.rArr.(O)k]- where k is 0 or 1; R1a is -H, - F, -Cl, -CN, -NO2, -(C1-C4) alkyl, -(C2-C4) alkynyl, fluorinated-(C1-C3) alkyl, fluorinated-(C1-C3) alkoxy, -OR16, or -C(=O)NR22aR22b; RA and RB are - H, -F, -CF3, -(C1-C4) alkyl, -(C3-C7) cycloalkyl, phenyl, or benzyl substituted by 0-3 R10; or RA and RB are taken together to form a spiro moiety of the formula (Ia) where r and s are 0-4 provided r + s is >=1 but not > 5; and XA is -CH2-, -CHF, -CF2, -NR15-, -O-, or -S(=O)t-, where t is 0, 1; RC and RD are the same as RA and RB except that one of them must be -H; R1 and R2 are -H, -F, -Cl, -CN, -NO2, -(C1-C4) alkyl, -(C2-C4) alkynyl, fluorinated-(C1-C3) alkyl, -OR16, or -C(=O)NR22aR22b; R3 is -H, -(C1-C3) alkyl, phenyl, benzyl, or -OR16; R4, R5 and R6, D, J1 and J2 are defined in the application.

Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of the formula (I) wherein j is 0 or 1, provided that when j is 0, n must be 2; k is 0 or 1; m is 1, 2, or 3; n is 1 or 2; W?1¿ and W?2¿ are -O-; -S(=O)¿t?-, where t is 0, 1, or 2, or -N(R?3¿)-; Y is =C(R?1¿¿a?)-, or -[N.rArr.(O)¿k?]- where k is 0 or 1; R?1¿¿a? is -H, -F, -Cl, -CN, -NO¿2?, -(C¿1?-C¿4?) alkyl, -(C¿2?-C¿4?) alkynyl, fluorinated-(C¿1?-C¿3?) alkyl, fluorinated-(C¿1?-C¿3?) alkoxy, -OR?16¿, or -C(=O)NR?22¿¿a?R?22¿¿b?; R?A¿ and R?B¿ are -H, -F, -CF¿3?, -(C¿1?-C¿4?) alkyl, -(C¿3?-C¿7?) cycloalkyl, phenyl, or benzyl substituted by 0-3 R?10¿; or R?A¿ and R?B¿ are taken together to form a spiro moiety of the formula (Ia) where r and s are 0-4 provided r + s is >=1 but not > 5; and X?A¿ is -CH¿2?-, -CHF, -CF¿2?, -NR?15¿-, -O-, or -S(=O)¿t?-, where t is 0, 1; R?C¿ and R?D¿ are the same as R?A¿ and R?B¿ except that one of them must be -H; R?1¿ and R?2¿ are -H, -F, -Cl, -CN, -NO¿2?, -(C¿1?-C¿4?) alkyl, -(C¿2?-C¿4?) alkynyl, fluorinated-(C¿1?-C¿3?) alkyl, -OR?16¿, or -C(=O)NR?22¿¿a?R?22¿¿b?; R?3¿ is -H, -(C¿1?-C¿3?) alkyl, phenyl, benzyl, or -OR?16¿; R?4¿, R?5¿ and R?6¿, D, J¿1? and J¿2? are defined in the application.

Affiliated with

Also associated with

Rating

Ether derivatives useful as inhibitors of pde4 isozymes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ether derivatives useful as inhibitors of pde4 isozymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ether derivatives useful as inhibitors of pde4 isozymes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1575923