C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/26 (2006.01) A61K 31/7048 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 37/02 (2006.01) C07F 9/655 (2006.01) C07H 7/027 (2006.01) C07H 13/06 (2006.01)
Patent
CA 2362246
Compounds represented by general formula (I), which have excellent macrophage inhibiting effects and are thus useful in the prevention or treatment of inflammation, autoimmune diseases or sepsis: wherein R1 and R3 are each C1-C20 alkanoyl which may be substituted with one or more members selected from the group consisting of halogeno, hydroxyl, oxo, C1-C20 alkoxy and C1-C20 alkanoyloxy; R2 and R4 are each C1-C20 alkyl which may be substituted with one or more members selected from the above group; and R5 is hydrogen, halogeno, hydroxyl, or C1-C6 alkoxy.
L'invention porte sur des composés de formule générale (I) présentant d'excellent effets d'inhibition des macrophages et s'avérant de ce fait utiles pour la prévention ou le traitement d'inflammations, de maladies auto-immunes ou de septicémies. Dans la formule, R?1¿ et R?3¿ sont chacun C¿1?-C¿20? alcanoyle facultativement substitué par un ou plusieurs éléments sélectionnés parmi halogéno, hydroxyle, oxo, C¿1?-C¿20? alkoxy, et C¿1?-C¿20? alcanoxy, R?2¿ et R?4¿ sont chacun C¿1?-C¿20? alkyle facultativement substitué par un ou plusieurs éléments du susdit groupe, et R?5¿ est H, halogéno, hydroxyle, ou C¿1?-C¿20? alkoxy.
Kanai Saori
Kazama Yukiko
Kurakata Shinichi
Shiozaki Masao
Marks & Clerk
Sankyo Company Limited
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