Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic...

Details Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic... Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic...

C - Chemistry, Metallurgy

07

D

167/238, 260/315

C07D 231/56 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2009503

Compounds and methods of preparation of compounds with the formula A-CH2-O-CRR'-COOR"' (I) where A is a 1-benzyl-indazol-3-yl nucleus of the formula (see formula II) R and R' may be the same or different and are H or C1-C5 alkyl, R"' is H or the residue of an aliphatic saturated alcohol having from 1 to 4 carbon atoms; and, when R"' is H, the salts thereof with pharmaceutically acceptable bases. The addition of a methylene group (-CH2-) between the 1-benzyl-indazol-3yl nucleus and the side claim (-O-CH2- COOR"') endows the compounds of Formula (I) with analgesic activity.

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