Ethyl 4-(8-chloro-5, 6-dihydro-11h- benzo[5,6]cyclohepta...

Details Ethyl 4-(8-chloro-5, 6-dihydro-11h- benzo[5,6]cyclohepta... Ethyl 4-(8-chloro-5, 6-dihydro-11h- benzo[5,6]cyclohepta...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2305801

A polymorph form 2 of ethyl 4-(8-chloro-5, 6-dihydro-11H- benzo[5,6]cyclohepta [1,2-b]pyridin -11-ylidene)-1- piperidene carboxylate (hereinafter "loratadine") represented by formula (I). Pharmaceutical composition containing the polymorph form 2, and methods of using the polymorph form 2 to treat allergic reactions in mammals such as man are disclosed.

On décrit une forme 2 d'un polymorphe d'éthyle 4-(8-chloro-5, 6,-dihydro-11H- benzo[5,6]cyclohepta [1,2-b]pyridine-11-ylidène)-1- pipéridène carboxylate (ci-après dénommé "loratadine") de la formule (I). On décrit également des compositions pharmaceutiques contenant la forme 2 dudit polymorphe et des procédés d'utilisation de ladite forme 2 pour traiter des réactions allergiques chez des mammifères comme l'être humain.

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