Ethyleneimine inactivated organisms

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) C12N 7/06 (2006.01)

Patent

CA 1038757

Abstract of the Disclosure Microorganism can be rendered inactive without impairing their antigenicity or immunogeni- city by treating the microorganism with ethylene- imine. The microorganism is placed in a suspension containing ethyleneimine up to a final concentration or 0.005% or 2% V/V. The temperature of the ethyleneimine-containing suspension is maintained between 0° C and 45° C for between a few hours and two days. The excess ethyleneimine is destroyed.

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